The ubiquitin ligation machinery in the defense against bacterial pathogens

EMBO Rep. 2021 Sep 13:e52864. doi: 10.15252/embr.202152864. Online ahead of print.

Authors: Ishita Tripathi-Giesgen, Christian Behrends, Arno F Alpi

PMID:34515402


SAMM50 acts with p62 in piecemeal basal- and OXPHOS-induced mitophagy of SAM and MICOS components

J Cell Biol. 2021 Aug 2;220(8):e202009092. doi: 10.1083/jcb.202009092. Epub 2021 May 26.

Authors: Yakubu Princely Abudu, Birendra Kumar Shrestha, Wenxin Zhang, Anthimi Palara, Hanne Britt Brenne, Kenneth Bowitz Larsen, Deanna Lynn Wolfson, Gianina Dumitriu, Cristina Ionica Øie, Balpreet Singh Ahluwalia, Gahl Levy, Christian Behrends, Sharon A Tooze, Stephane Mouilleron, Trond Lamark, Terje Johansen

PMID:34037656


Autophagosome content profiling using proximity biotinylation proteomics coupled to protease digestion in mammalian cells

STAR Protoc. 2021 Apr 27;2(2):100506. doi: 10.1016/j.xpro.2021.100506. eCollection 2021 Jun 18.

Authors: Susanne Zellner, Karsten Nalbach, Christian Behrends

PMID:33997820


TFG binds LC3C to regulate ULK1 localization and autophagosome formation

EMBO J. 2021 May 17;40(10):e103563. doi: 10.15252/embj.2019103563. Epub 2021 May 1.

Authors: Marianna Carinci, Beatrice Testa, Matteo Bordi, Giacomo Milletti, Massimo Bonora, Laura Antonucci, Caterina Ferraina, Marta Carro, Mukesh Kumar, Donatella Ceglie, Franziska Eck, Roberta Nardacci, Francois le Guerroué, Stefania Petrini, Maria E Soriano, Ignazio Caruana, Valentina Doria, Maria Manifava, Camille Peron, Matteo Lambrughi, Valeria Tiranti, Christian Behrends, Elena Papaleo, Paolo Pinton, Carlotta Giorgi, Nicholas T Ktistakis, Franco Locatelli, Francesca Nazio, Francesco Cecconi

PMID:33932238


Clinical, neuroimaging, and molecular spectrum of TECPR2-associated hereditary sensory and autonomic neuropathy with intellectual disability

Hum Mutat. 2021 Jun;42(6):762-776. doi: 10.1002/humu.24206. Epub 2021 May 11.

Authors: Sonja Neuser, Barbara Brechmann, Gali Heimer, Ines Brösse, Susanna Schubert, Lauren O'Grady, Michael Zech, Siddharth Srivastava, David A Sweetser, Yasemin Dincer, Volker Mall, Juliane Winkelmann, Christian Behrends, Basil T Darras, Robert J Graham, Parul Jayakar, Barry Byrne, Bat El Bar-Aluma, Yael Haberman, Amir Szeinberg, Hesham M Aldhalaan, Mais Hashem, Amal Al Tenaiji, Omar Ismayl, Asma E Al Nuaimi, Karima Maher, Shahnaz Ibrahim, Fatima Khan, Henry Houlden, Vijayalakshmi S Ramakumaran, Alistair T Pagnamenta, Jennifer E Posey, James R Lupski, Wen-Hann Tan, Gehad ElGhazali, Isabella Herman, Tatiana Muñoz, Gabriela M Repetto, Angelika Seitz, Mandy Krumbiegel, Maria Cecilia Poli, Usha Kini, Stephanie Efthymiou, Jens Meiler, Reza Maroofian, Fowzan S Alkuraya, Rami Abou Jamra, Bernt Popp, Bruria Ben-Zeev, Darius Ebrahimi-Fakhari

PMID:33847017


Autophagosome content profiling reveals receptor-specific cargo candidates

Autophagy. 2021 May;17(5):1281-1283. doi: 10.1080/15548627.2021.1909410. Epub 2021 Apr 5.

Authors: Susanne Zellner, Christian Behrends

PMID:33779494


ATG4 family proteins drive phagophore growth independently of the LC3/GABARAP lipidation system

Mol Cell. 2021 May 6;81(9):2013-2030.e9. doi: 10.1016/j.molcel.2021.03.001. Epub 2021 Mar 26.

Authors: Thanh Ngoc Nguyen, Benjamin Scott Padman, Susanne Zellner, Grace Khuu, Louise Uoselis, Wai Kit Lam, Marvin Skulsuppaisarn, Runa S J Lindblom, Emily M Watts, Christian Behrends, Michael Lazarou

PMID:33773106


Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling

Mol Cell. 2021 Mar 18;81(6):1337-1354.e8. doi: 10.1016/j.molcel.2021.01.009. Epub 2021 Feb 4.

Authors: Susanne Zellner, Martina Schifferer, Christian Behrends

PMID:33545068


Model-based comparison of organ at risk protection between VMAT and robustly optimised IMPT plans

Z Med Phys. 2021 Feb;31(1):5-15. doi: 10.1016/j.zemedi.2020.09.003. Epub 2020 Dec 22.

Authors: Carina Behrends, Jan Haussmann, P-H Kramer, Johannes A Langendijk, Holger Gottschlag, Dirk Geismar, Wilfried Budach, Beate Timmermann

PMID:33358063


A tecpr2 knockout mouse exhibits age-dependent neuroaxonal dystrophy associated with autophagosome accumulation

Autophagy. 2020 Dec 10:1-14. doi: 10.1080/15548627.2020.1852724. Online ahead of print.

Authors: Bat-Chen Tamim-Yecheskel, Milana Fraiberg, Kamilya Kokabi, Saskia Freud, Oren Shatz, Letizia Marvaldi, Nemanja Subic, Ori Brenner, Michael Tsoory, Raya Eilam-Altstadter, Inbal Biton, Alon Savidor, Nili Dezorella, Gali Heimer, Christian Behrends, Bruria Ben-Zeev, Zvulun Elazar

PMID:33218264


Lysosomal targeting of autophagosomes by the TECPR domain of TECPR2

Autophagy. 2020 Nov 29:1-13. doi: 10.1080/15548627.2020.1852727. Online ahead of print.

Authors: Milana Fraiberg, Bat-Chen Tamim-Yecheskel, Kamilya Kokabi, Nemanja Subic, Gali Heimer, Franziska Eck, Karsten Nalbach, Christian Behrends, Bruria Ben-Zeev, Oren Shatz, Zvulun Elazar

PMID:33213269


BAG3 Proteomic Signature under Proteostasis Stress

Cells. 2020 Nov 4;9(11):2416. doi: 10.3390/cells9112416.

Authors: Christof Hiebel, Elisabeth Stürner, Meike Hoffmeister, Georg Tascher, Mario Schwarz, Heike Nagel, Christian Behrends, Christian Münch, Christian Behl

PMID:33158300


Canonical and non-canonical autophagy pathways in microglia

Mol Cell Biol. 2020 Nov 2;41(3):e00389-20. doi: 10.1128/MCB.00389-20. Online ahead of print.

Authors: Julia Jülg, Laura Strohm, Christian Behrends

PMID:33139495


ACSL3 is a novel GABARAPL2 interactor that links ufmylation and lipid droplet biogenesis

J Cell Sci. 2020 Sep 16;133(18):jcs243477. doi: 10.1242/jcs.243477.

Authors: Franziska Eck, Santosh Phuyal, Matthew D Smith, Manuel Kaulich, Simon Wilkinson, Hesso Farhan, Christian Behrends

PMID:32843575


Hepatic Rab24 controls blood glucose homeostasis via improving mitochondrial plasticity

Nat Metab. 2019 Oct;1(10):1009-1026. doi: 10.1038/s42255-019-0124-x. Epub 2019 Oct 14.

Authors: Susanne Seitz, Yun Kwon, Götz Hartleben, Julia Jülg, Revathi Sekar, Natalie Krahmer, Bahar Najafi, Anne Loft, Sofiya Gancheva, Kerstin Stemmer, Annette Feuchtinger, Martin Hrabe de Angelis, Timo D Müller, Matthias Mann, Matthias Blüher, Michael Roden, Mauricio Berriel Diaz, Christian Behrends, Jerome Gilleron, Stephan Herzig, Anja Zeigerer

PMID:32694843


AMPK is activated during lysosomal damage via a galectin-ubiquitin signal transduction system

Autophagy. 2020 Aug;16(8):1550-1552. doi: 10.1080/15548627.2020.1788890. Epub 2020 Jul 25.

Authors: Jingyue Jia, Bhawana Bissa, Lukas Brecht, Lee Allers, Seong Won Choi, Yuexi Gu, Mark Zbinden, Mark R Burge, Graham Timmins, Kenneth Hallows, Christian Behrends, Vojo Deretic

PMID:32597364


The GABARAP Co-Secretome Identified by APEX2-GABARAP Proximity Labelling of Extracellular Vesicles

Cells. 2020 Jun 16;9(6):1468. doi: 10.3390/cells9061468.

Authors: Julia L Sanwald, Gereon Poschmann, Kai Stühler, Christian Behrends, Silke Hoffmann, Dieter Willbold

PMID:32560054


NRBF2 is a RAB7 effector required for autophagosome maturation and mediates the association of APP-CTFs with active form of RAB7 for degradation

Autophagy. 2021 May;17(5):1112-1130. doi: 10.1080/15548627.2020.1760623. Epub 2020 Jun 16.

Authors: Cui-Zan Cai, Chuanbin Yang, Xu-Xu Zhuang, Ning-Ning Yuan, Ming-Yue Wu, Jie-Qiong Tan, Ju-Xian Song, King-Ho Cheung, Huanxing Su, Yi-Tao Wang, Bei-Sha Tang, Christian Behrends, Siva Sundara Kumar Durairajan, Zhenyu Yue, Min Li, Jia-Hong Lu

PMID:32543313


When Separation Causes Activation: Biophysical Control of Bulk Autophagy Initiation

Mol Cell. 2020 May 7;78(3):379-381. doi: 10.1016/j.molcel.2020.04.015.

Authors: Debjani Bhattacharya, Christian Behrends

PMID:32386541


How simulation modeling can support the public health response to the opioid crisis in North America: Setting priorities and assessing value

Int J Drug Policy. 2021 Feb;88:102726. doi: 10.1016/j.drugpo.2020.102726. Epub 2020 Apr 28.

Authors: OUD Modeling writing group

PMID:32359858


AMPK, a Regulator of Metabolism and Autophagy, Is Activated by Lysosomal Damage via a Novel Galectin-Directed Ubiquitin Signal Transduction System

Mol Cell. 2020 Mar 5;77(5):951-969.e9. doi: 10.1016/j.molcel.2019.12.028. Epub 2020 Jan 28.

Authors: Jingyue Jia, Bhawana Bissa, Lukas Brecht, Lee Allers, Seong Won Choi, Yuexi Gu, Mark Zbinden, Mark R Burge, Graham Timmins, Kenneth Hallows, Christian Behrends, Vojo Deretic

PMID:31995728


Molecular Mechanisms of Selective Autophagy

J Mol Biol. 2020 Jan 3;432(1):1-2. doi: 10.1016/j.jmb.2019.11.010. Epub 2019 Dec 4.

Authors: Sascha Martens, Christian Behrends

PMID:31839401


Regulation of lysosome integrity and lysophagy by the ubiquitin-conjugating enzyme UBE2QL1

Autophagy. 2020 Jan;16(1):179-180. doi: 10.1080/15548627.2019.1687217. Epub 2019 Nov 6.

Authors: Bojana Kravic, Christian Behrends, Hemmo Meyer

PMID:31679434


The ubiquitin-conjugating enzyme UBE2QL1 coordinates lysophagy in response to endolysosomal damage

EMBO Rep. 2019 Oct 4;20(10):e48014. doi: 10.15252/embr.201948014. Epub 2019 Aug 21.

Authors: Lisa Koerver, Chrisovalantis Papadopoulos, Bin Liu, Bojana Kravic, Giulia Rota, Lukas Brecht, Tineke Veenendaal, Mira Polajnar, Anika Bluemke, Michael Ehrmann, Judith Klumperman, Marja Jäättelä, Christian Behrends, Hemmo Meyer

PMID:31432621


Loss of Peter Pan (PPAN) Affects Mitochondrial Homeostasis and Autophagic Flux

Cells. 2019 Aug 14;8(8):894. doi: 10.3390/cells8080894.

Authors: David P Dannheisig, Eileen Beck, Enrico Calzia, Paul Walther, Christian Behrends, Astrid S Pfister

PMID:31416196


RITA modulates cell migration and invasion by affecting focal adhesion dynamics

Mol Oncol. 2019 Oct;13(10):2121-2141. doi: 10.1002/1878-0261.12551. Epub 2019 Aug 6.

Authors: Samira Catharina Hoock, Andreas Ritter, Kerstin Steinhäuser, Susanne Roth, Christian Behrends, Franz Oswald, Christine Solbach, Frank Louwen, Nina-Naomi Kreis, Juping Yuan

PMID:31353815


Increased Immune Activation by Pathologic alpha-Synuclein in Parkinson's Disease

Ann Neurol. 2019 Oct;86(4):593-606. doi: 10.1002/ana.25557. Epub 2019 Aug 15.

Authors: Veselin Grozdanov, Luc Bousset, Meike Hoffmeister, Corinna Bliederhaeuser, Christoph Meier, Karine Madiona, Laura Pieri, Martin Kiechle, Pamela J McLean, Jan Kassubek, Christian Behrends, Albert C Ludolph, Jochen H Weishaupt, Ronald Melki, Karin M Danzer

PMID:31343083


The Hippo network kinase STK38 contributes to protein homeostasis by inhibiting BAG3-mediated autophagy

Biochim Biophys Acta Mol Cell Res. 2019 Oct;1866(10):1556-1566. doi: 10.1016/j.bbamcr.2019.07.007. Epub 2019 Jul 19.

Authors: Christina Klimek, Ricarda Jahnke, Judith Wördehoff, Barbara Kathage, Daniela Stadel, Christian Behrends, Alexander Hergovich, Jörg Höhfeld

PMID:31326538


Autophagy, Inflammation, and Metabolism (AIM) Center in its second year

Autophagy. 2019 Oct;15(10):1829-1833. doi: 10.1080/15548627.2019.1634444. Epub 2019 Jul 15.

Authors: Vojo Deretic, Eric Prossnitz, Mark Burge, Matthew J Campen, Judy Cannon, Ke Jian Liu, Meilian Liu, Pamela Hall, Larry A Sklar, Lee Allers, Luisa Mariscal, Sally Ann Garcia, John Weaver, Eric H Baehrecke, Christian Behrends, Francesco Cecconi, Patrice Codogno, Guang-Chao Chen, Zvulun Elazar, Eeva-Liisa Eskelinen, Bernard Fourie, Devrim Gozuacik, Wanjin Hong, Eun-Kyeong Jo, Terje Johansen, Gábor Juhász, Adi Kimchi, Nicholas Ktistakis, Guido Kroemer, Noboru Mizushima, Christian Münz, Fulvio Reggiori, David Rubinsztein, Kevin Ryan, Kate Schroder, Han-Min Shen, Anne Simonsen, Sharon A Tooze, Maria Vaccaro, Tamotsu Yoshimori, Li Yu, Hong Zhang, Daniel J Klionsky

PMID:31234750


LTK is an ER-resident receptor tyrosine kinase that regulates secretion

J Cell Biol. 2019 Aug 5;218(8):2470-2480. doi: 10.1083/jcb.201903068. Epub 2019 Jun 21.

Authors: Federica G Centonze, Veronika Reiterer, Karsten Nalbach, Kota Saito, Krzysztof Pawlowski, Christian Behrends, Hesso Farhan

PMID:31227593


Glia-specific autophagy dysfunction in ALS

Semin Cell Dev Biol. 2020 Mar;99:172-182. doi: 10.1016/j.semcdb.2019.05.024. Epub 2019 May 28.

Authors: Laura Strohm, Christian Behrends

PMID:31132469


Regulation of death receptor signaling by the autophagy protein TP53INP2

EMBO J. 2019 May 15;38(10):e99300. doi: 10.15252/embj.201899300. Epub 2019 Apr 12.

Authors: Saška Ivanova, Mira Polajnar, Alvaro Jesus Narbona-Perez, Maria Isabel Hernandez-Alvarez, Petra Frager, Konstantin Slobodnyuk, Natalia Plana, Angel R Nebreda, Manuel Palacin, Roger R Gomis, Christian Behrends, Antonio Zorzano

PMID:30979779


Lysosomal targeting of the ABC transporter TAPL is determined by membrane-localized charged residues

J Biol Chem. 2019 May 3;294(18):7308-7323. doi: 10.1074/jbc.RA118.007071. Epub 2019 Mar 15.

Authors: Philipp Graab, Christoph Bock, Konstantin Weiss, Alexander Hirth, Nicole Koller, Markus Braner, Jennifer Jung, Frank Loehr, Robert Tampé, Christian Behrends, Rupert Abele

PMID:30877195


Multiple molecular pathways stimulating macroautophagy protect from alpha-synuclein-induced toxicity in human neurons

Neuropharmacology. 2019 May 1;149:13-26. doi: 10.1016/j.neuropharm.2019.01.023. Epub 2019 Feb 4.

Authors: Matthias Höllerhage, Natascha Fussi, Thomas W Rösler, Wolfgang Wurst, Christian Behrends, Günter U Höglinger

PMID:30731136


Loss of the selective autophagy receptor p62 impairs murine myeloid leukemia progression and mitophagy

Blood. 2019 Jan 10;133(2):168-179. doi: 10.1182/blood-2018-02-833475. Epub 2018 Nov 29.

Authors: The Duy Nguyen, Shabnam Shaid, Olesya Vakhrusheva, Sebastian E Koschade, Kevin Klann, Marlyn Thölken, Fatima Baker, Jing Zhang, Thomas Oellerich, Duran Sürün, Anja Derlet, Isabella Haberbosch, Stefan Eimer, Heinz D Osiewacz, Christian Behrends, Christian Münch, Ivan Dikic, Christian H Brandts

PMID:30498063


Exosomal secretion of α-synuclein as protective mechanism after upstream blockage of macroautophagy

Cell Death Dis. 2018 Jul 9;9(7):757. doi: 10.1038/s41419-018-0816-2.

Authors: Natascha Fussi, Matthias Höllerhage, Tasnim Chakroun, Niko-Petteri Nykänen, Thomas W Rösler, Thomas Koeglsperger, Wolfgang Wurst, Christian Behrends, Günter U Höglinger

PMID:29988147


Cellular Mechanisms Controlling Surfacing of AICL Glycoproteins, Cognate Ligands of the Activating NK Receptor NKp80

J Immunol. 2018 Aug 15;201(4):1275-1286. doi: 10.4049/jimmunol.1800059. Epub 2018 Jul 6.

Authors: Sebastian Neuss, Yvonne Bartel, Christina Born, Sandra Weil, Joachim Koch, Christian Behrends, Meike Hoffmeister, Alexander Steinle

PMID:29980609


Autophagy, Inflammation, and Metabolism (AIM) Center of Biomedical Research Excellence: supporting the next generation of autophagy researchers and fostering international collaborations

Autophagy. 2018;14(6):925-929. doi: 10.1080/15548627.2018.1465784.

Authors: Vojo Deretic, Eric Prossnitz, Mark Burge, Matthew J Campen, Judy Cannon, Ke Jian Liu, Larry A Sklar, Lee Allers, Sally Ann Garcia, Eric H Baehrecke, Christian Behrends, Francesco Cecconi, Patrice Codogno, Guang-Chao Chen, Zvulun Elazar, Eeva-Liisa Eskelinen, Bernard Fourie, Devrim Gozuacik, Wanjin Hong, Gokhan Hotamisligi, Marja Jäättelä, Eun-Kyeong Jo, Terje Johansen, Gábor Juhász, Adi Kimchi, Nicholas Ktistakis, Guido Kroemer, Noboru MIzushima, Christian Münz, Fulvio Reggiori, David Rubinsztein, Kevin Ryan, Kate Schroder, Anne Simonsen, Sharon Tooze, Maria I Vaccaro, Tamotsu Yoshimori, Li Yu, Hong Zhang, Daniel J Klionsky

PMID:29938597


AT 101 induces early mitochondrial dysfunction and HMOX1 (heme oxygenase 1) to trigger mitophagic cell death in glioma cells

Autophagy. 2018;14(10):1693-1709. doi: 10.1080/15548627.2018.1476812. Epub 2018 Jul 21.

Authors: Nina Meyer, Svenja Zielke, Jonas B Michaelis, Benedikt Linder, Verena Warnsmann, Stefanie Rakel, Heinz D Osiewacz, Simone Fulda, Michel Mittelbronn, Christian Münch, Christian Behrends, Donat Kögel

PMID:29938581


Arginine Methylation Regulates MEIS2 Nuclear Localization to Promote Neuronal Differentiation of Adult SVZ Progenitors

Stem Cell Reports. 2018 Apr 10;10(4):1184-1192. doi: 10.1016/j.stemcr.2018.03.010.

Authors: Jasmine Kolb, Marie Anders-Maurer, Tanja Müller, Ann-Christin Hau, Britta Moyo Grebbin, Wiebke Kallenborn-Gerhardt, Christian Behrends, Dorothea Schulte

PMID:29641989


The pseudophosphatase STYX targets the F-box of FBXW7 and inhibits SCF<sup>FBXW</sup><sup>7</sup> function

EMBO J. 2018 Mar 15;37(6):e99170. doi: 10.15252/embj.201899170.

Authors: Veronika Reiterer, Cristina Figueras-Puig, Francois Le Guerroue, Stefano Confalonieri, Manuela Vecchi, Dasaradha Jalapothu, Sandip M Kanse, Raymond J Deshaies, Pier Paolo Di Fiore, Christian Behrends, Hesso Farhan

PMID:29545456


Oocyte DNA damage quality control requires consecutive interplay of CHK2 and CK1 to activate p63

Nat Struct Mol Biol. 2018 Mar;25(3):261-269. doi: 10.1038/s41594-018-0035-7. Epub 2018 Feb 26.

Authors: Marcel Tuppi, Sebastian Kehrloesser, Daniel W Coutandin, Valerio Rossi, Laura M Luh, Alexander Strubel, Katharina Hötte, Meike Hoffmeister, Birgit Schäfer, Tiago De Oliveira, Florian Greten, Ernst H K Stelzer, Stefan Knapp, Massimo De Felici, Christian Behrends, Francesca Gioia Klinger, Volker Dötsch

PMID:29483652


CCPG1 Is a Non-canonical Autophagy Cargo Receptor Essential for ER-Phagy and Pancreatic ER Proteostasis

Dev Cell. 2018 Jan 22;44(2):217-232.e11. doi: 10.1016/j.devcel.2017.11.024. Epub 2017 Dec 28.

Authors: Matthew D Smith, Margaret E Harley, Alain J Kemp, Jimi Wills, Martin Lee, Mark Arends, Alex von Kriegsheim, Christian Behrends, Simon Wilkinson

PMID:29290589


Autophagosomal Content Profiling Reveals an LC3C-Dependent Piecemeal Mitophagy Pathway

Mol Cell. 2017 Nov 16;68(4):786-796.e6. doi: 10.1016/j.molcel.2017.10.029.

Authors: François Le Guerroué, Franziska Eck, Jennifer Jung, Tatjana Starzetz, Michel Mittelbronn, Manuel Kaulich, Christian Behrends

PMID:29149599


Autophagy acts through TRAF3 and RELB to regulate gene expression via antagonism of SMAD proteins

Nat Commun. 2017 Nov 16;8(1):1537. doi: 10.1038/s41467-017-00859-z.

Authors: Alice C Newman, Alain J Kemp, Yvette Drabsch, Christian Behrends, Simon Wilkinson

PMID:29146913


Effects of soluble CPE on glioma cell migration are associated with mTOR activation and enhanced glucose flux

Oncotarget. 2017 Jun 27;8(40):67567-67591. doi: 10.18632/oncotarget.18747. eCollection 2017 Sep 15.

Authors: Elena I Ilina, Angela Armento, Leticia Garea Sanchez, Marina Reichlmeir, Yannick Braun, Cornelia Penski, David Capper, Felix Sahm, Lukas Jennewein, Patrick N Harter, Sven Zukunft, Ingrid Fleming, Dorothea Schulte, Francois Le Guerroué, Christian Behrends, Michael W Ronellenfitsch, Ulrike Naumann, Michel Mittelbronn

PMID:28978054


Protocol for Establishing a Multiplex Image-based Autophagy RNAi Screen in Cell Cultures

Bio Protoc. 2017 Sep 5;7(17):27982478. doi: 10.21769/BioProtoc.2540.

Authors: Jennifer Jung, Christian Behrends

PMID:28966949


Phospho-Rasputin Stabilization by Sec16 Is Required for Stress Granule Formation upon Amino Acid Starvation

Cell Rep. 2017 Aug 29;20(9):2277. doi: 10.1016/j.celrep.2017.08.054.

Authors: Angelica Aguilera-Gomez, Margarita Zacharogianni, Marinke M van Oorschot, Heide Genau, Rianne Grond, Tineke Veenendaal, Kristina S Sinsimer, Elisabeth A Gavis, Christian Behrends, Catherine Rabouille

PMID:28854374


Site-specific inhibition of the small ubiquitin-like modifier (SUMO)-conjugating enzyme Ubc9 selectively impairs SUMO chain formation

J Biol Chem. 2017 Sep 15;292(37):15340-15351. doi: 10.1074/jbc.M117.794255. Epub 2017 Aug 7.

Authors: Svenja Wiechmann, Anne Gärtner, Andreas Kniss, Andreas Stengl, Christian Behrends, Vladimir V Rogov, Manuel S Rodriguez, Volker Dötsch, Stefan Müller, Andreas Ernst

PMID:28784659


Expanding the host cell ubiquitylation machinery targeting cytosolic <em>Salmonella</em>

EMBO Rep. 2017 Sep;18(9):1572-1585. doi: 10.15252/embr.201643851. Epub 2017 Aug 6.

Authors: Mira Polajnar, Marina S Dietz, Mike Heilemann, Christian Behrends

PMID:28784601


Phospho-Rasputin Stabilization by Sec16 Is Required for Stress Granule Formation upon Amino Acid Starvation

Cell Rep. 2017 Jul 25;20(4):935-948. doi: 10.1016/j.celrep.2017.06.042.

Authors: Angelica Aguilera-Gomez, Margarita Zacharogianni, Marinke M van Oorschot, Heide Genau, Rianne Grond, Tineke Veenendaal, Kristina S Sinsimer, Elizabeth R Gavis, Christian Behrends, Catherine Rabouille

PMID:28746877


Multifaceted role of SMCR8 as autophagy regulator

Small GTPases. 2020 Jan;11(1):53-61. doi: 10.1080/21541248.2017.1346553. Epub 2017 Oct 3.

Authors: Jennifer Jung, Christian Behrends

PMID:28696821


Multiplex image-based autophagy RNAi screening identifies SMCR8 as ULK1 kinase activity and gene expression regulator

Elife. 2017 Feb 14;6:e23063. doi: 10.7554/eLife.23063.

Authors: Jennifer Jung, Arnab Nayak, Véronique Schaeffer, Tatjana Starzetz, Achim K Kirsch, Stefan Müller, Ivan Dikic, Michel Mittelbronn, Christian Behrends

PMID:28195531


The pseudophosphatase STYX targets the F-box of FBXW7 and inhibits SCFFBXW7 function

EMBO J. 2017 Feb 1;36(3):260-273. doi: 10.15252/embj.201694795. Epub 2016 Dec 22.

Authors: Veronika Reiterer, Cristina Figueras-Puig, Francois Le Guerroue, Stefano Confalonieri, Manuela Vecchi, Dasaradha Jalapothu, Sandip M Kanse, Raymond J Deshaies, Pier Paolo Di Fiore, Christian Behrends, Hesso Farhan

PMID:28007894


Progranulin overexpression in sensory neurons attenuates neuropathic pain in mice: Role of autophagy

Neurobiol Dis. 2016 Dec;96:294-311. doi: 10.1016/j.nbd.2016.09.010. Epub 2016 Sep 11.

Authors: Christine Altmann, Stefanie Hardt, Caroline Fischer, Juliana Heidler, Hee-Young Lim, Annett Häussler, Boris Albuquerque, Béla Zimmer, Christine Möser, Christian Behrends, Frank Koentgen, Ilka Wittig, Mirko H H Schmidt, Albrecht M Clement, Thomas Deller, Irmgard Tegeder

PMID:27629805


An siRNA screen for ATG protein depletion reveals the extent of the unconventional functions of the autophagy proteome in virus replication

J Cell Biol. 2016 Aug 29;214(5):619-35. doi: 10.1083/jcb.201602046.

Authors: Mario Mauthe, Martijn Langereis, Jennifer Jung, Xingdong Zhou, Alex Jones, Wienand Omta, Sharon A Tooze, Björn Stork, Søren Riis Paludan, Tero Ahola, Dave Egan, Christian Behrends, Michal Mokry, Cornelis de Haan, Frank van Kuppeveld, Fulvio Reggiori

PMID:27573464


Unveiling ubiquitinome rearrangements induced by Salmonella infection

Autophagy. 2016 Sep;12(9):1683-4. doi: 10.1080/15548627.2016.1203490. Epub 2016 Jul 28.

Authors: Tihana Bionda, Christian Behrends

PMID:27467224


GABARAP proteins as scaffolds in localized TIAM1-RAC1 signaling

Mol Cell Oncol. 2015 Apr 14;3(1):e1027440. doi: 10.1080/23723556.2015.1027440. eCollection 2016 Jan.

Authors: Heide Marika Genau, Christian Behrends

PMID:27308540


Global Analysis of Host and Bacterial Ubiquitinome in Response to Salmonella Typhimurium Infection

Mol Cell. 2016 Jun 16;62(6):967-981. doi: 10.1016/j.molcel.2016.04.015. Epub 2016 May 19.

Authors: Evgenij Fiskin, Tihana Bionda, Ivan Dikic, Christian Behrends

PMID:27211868


Diagnostic and clinical relevance of the autophago-lysosomal network in human gliomas

Oncotarget. 2016 Apr 12;7(15):20016-32. doi: 10.18632/oncotarget.7910.

Authors: Lukas Jennewein, Michael W Ronellenfitsch, Patrick Antonietti, Elena I Ilina, Jennifer Jung, Daniela Stadel, Lisa-Marie Flohr, Jenny Zinke, Janusz von Renesse, Ulrich Drott, Peter Baumgarten, Anne K Braczynski, Cornelia Penski, Michael C Burger, Jean-Philippe Theurillat, Joachim P Steinbach, Karl-Heinz Plate, Ivan Dikic, Simone Fulda, Christian Brandts, Donat Kögel, Christian Behrends, Patrick N Harter, Michel Mittelbronn

PMID:26956048


TBC1D14 regulates autophagy via the TRAPP complex and ATG9 traffic

EMBO J. 2016 Feb 1;35(3):281-301. doi: 10.15252/embj.201592695. Epub 2015 Dec 28.

Authors: Christopher A Lamb, Stefanie Nühlen, Delphine Judith, David Frith, Ambrosius P Snijders, Christian Behrends, Sharon A Tooze

PMID:26711178


TECPR2 Cooperates with LC3C to Regulate COPII-Dependent ER Export

Mol Cell. 2015 Oct 1;60(1):89-104. doi: 10.1016/j.molcel.2015.09.010.

Authors: Daniela Stadel, Valentina Millarte, Kerstin D Tillmann, Jessica Huber, Bat-Chen Tamin-Yecheskel, Masato Akutsu, Alik Demishtein, Bruria Ben-Zeev, Yair Anikster, Franck Perez, Volker Dötsch, Zvulun Elazar, Vladimir Rogov, Hesso Farhan, Christian Behrends

PMID:26431026


Amino Acid-Dependent mTORC1 Regulation by the Lysosomal Membrane Protein SLC38A9

Mol Cell Biol. 2015 Jul;35(14):2479-94. doi: 10.1128/MCB.00125-15. Epub 2015 May 11.

Authors: Jennifer Jung, Heide Marika Genau, Christian Behrends

PMID:25963655


CUL3-KBTBD6/KBTBD7 ubiquitin ligase cooperates with GABARAP proteins to spatially restrict TIAM1-RAC1 signaling

Mol Cell. 2015 Mar 19;57(6):995-1010. doi: 10.1016/j.molcel.2014.12.040. Epub 2015 Feb 12.

Authors: Heide Marika Genau, Jessica Huber, Francesco Baschieri, Masato Akutsu, Volker Dötsch, Hesso Farhan, Vladimir Rogov, Christian Behrends

PMID:25684205


PLEKHM1 regulates autophagosome-lysosome fusion through HOPS complex and LC3/GABARAP proteins

Mol Cell. 2015 Jan 8;57(1):39-54. doi: 10.1016/j.molcel.2014.11.006. Epub 2014 Dec 11.

Authors: David G McEwan, Doris Popovic, Andrea Gubas, Seigo Terawaki, Hironori Suzuki, Daniela Stadel, Fraser P Coxon, Diana Miranda de Stegmann, Sagar Bhogaraju, Karthik Maddi, Anja Kirchof, Evelina Gatti, Miep H Helfrich, Soichi Wakatsuki, Christian Behrends, Philippe Pierre, Ivan Dikic

PMID:25498145


RAB3GAP1 and RAB3GAP2 modulate basal and rapamycin-induced autophagy

Autophagy. 2014;10(12):2297-309. doi: 10.4161/15548627.2014.994359.

Authors: Natalie Spang, Anne Feldmann, Heike Huesmann, Fazilet Bekbulat, Verena Schmitt, Christof Hiebel, Ingrid Koziollek-Drechsler, Albrecht M Clement, Bernd Moosmann, Jennifer Jung, Christian Behrends, Ivan Dikic, Andreas Kern, Christian Behl

PMID:25495476


Autophagy-dependent PELI3 degradation inhibits proinflammatory IL1B expression

Autophagy. 2014;10(11):1937-52. doi: 10.4161/auto.32178. Epub 2014 Oct 30.

Authors: Annika Klara Giegerich, Laura Kuchler, Lisa Katharina Sha, Tilo Knape, Heinrich Heide, Ilka Wittig, Christian Behrends, Bernhard Brüne, Andreas von Knethen

PMID:25483963


FLCN, a novel autophagy component, interacts with GABARAP and is regulated by ULK1 phosphorylation

Autophagy. 2014 Oct 1;10(10):1749-60. doi: 10.4161/auto.29640. Epub 2014 Jul 22.

Authors: Elaine A Dunlop, Sara Seifan, Tijs Claessens, Christian Behrends, Miriam Af Kamps, Ewelina Rozycka, Alain J Kemp, Ravi K Nookala, John Blenis, Barry J Coull, James T Murray, Maurice Am van Steensel, Simon Wilkinson, Andrew R Tee

PMID:25126726


NRBF2 regulates autophagy and prevents liver injury by modulating Atg14L-linked phosphatidylinositol-3 kinase III activity

Nat Commun. 2014 May 22;5:3920. doi: 10.1038/ncomms4920.

Authors: Jiahong Lu, Liqiang He, Christian Behrends, Masatake Araki, Kimi Araki, Qing Jun Wang, Joseph M Catanzaro, Scott L Friedman, Wei-Xing Zong, M Isabel Fiel, Min Li, Zhenyu Yue

PMID:24849286


Cellular mechanotransduction relies on tension-induced and chaperone-assisted autophagy

Curr Biol. 2013 Mar 4;23(5):430-5. doi: 10.1016/j.cub.2013.01.064. Epub 2013 Feb 21.

Authors: Anna Ulbricht, Felix J Eppler, Victor E Tapia, Peter F M van der Ven, Nico Hampe, Nils Hersch, Padmanabhan Vakeel, Daniela Stadel, Albert Haas, Paul Saftig, Christian Behrends, Dieter O Fürst, Rudolf Volkmer, Bernd Hoffmann, Waldemar Kolanus, Jörg Höhfeld

PMID:23434281


Guidelines for the use and interpretation of assays for monitoring autophagy

Autophagy. 2012 Apr;8(4):445-544. doi: 10.4161/auto.19496.

Authors: Daniel J Klionsky, Fabio C Abdalla, Hagai Abeliovich, Robert T Abraham, Abraham Acevedo-Arozena, Khosrow Adeli, Lotta Agholme, Maria Agnello, Patrizia Agostinis, Julio A Aguirre-Ghiso, Hyung Jun Ahn, Ouardia Ait-Mohamed, Slimane Ait-Si-Ali, Takahiko Akematsu, Shizuo Akira, Hesham M Al-Younes, Munir A Al-Zeer, Matthew L Albert, Roger L Albin, Javier Alegre-Abarrategui, Maria Francesca Aleo, Mehrdad Alirezaei, Alexandru Almasan, Maylin Almonte-Becerril, Atsuo Amano, Ravi Amaravadi, Shoba Amarnath, Amal O Amer, Nathalie Andrieu-Abadie, Vellareddy Anantharam, David K Ann, Shailendra Anoopkumar-Dukie, Hiroshi Aoki, Nadezda Apostolova, Giuseppe Arancia, John P Aris, Katsuhiko Asanuma, Nana Y O Asare, Hisashi Ashida, Valerie Askanas, David S Askew, Patrick Auberger, Misuzu Baba, Steven K Backues, Eric H Baehrecke, Ben A Bahr, Xue-Yuan Bai, Yannick Bailly, Robert Baiocchi, Giulia Baldini, Walter Balduini, Andrea Ballabio, Bruce A Bamber, Edward T W Bampton, Gábor Bánhegyi, Clinton R Bartholomew, Diane C Bassham, Robert C Bast, Henri Batoko, Boon-Huat Bay, Isabelle Beau, Daniel M Béchet, Thomas J Begley, Christian Behl, Christian Behrends, Soumeya Bekri, Bryan Bellaire, Linda J Bendall, Luca Benetti, Laura Berliocchi, Henri Bernardi, Francesca Bernassola, Sébastien Besteiro, Ingrid Bhatia-Kissova, Xiaoning Bi, Martine Biard-Piechaczyk, Janice S Blum, Lawrence H Boise, Paolo Bonaldo, David L Boone, Beat C Bornhauser, Karina R Bortoluci, Ioannis Bossis, Frédéric Bost, Jean-Pierre Bourquin, Patricia Boya, Michaël Boyer-Guittaut, Peter V Bozhkov, Nathan R Brady, Claudio Brancolini, Andreas Brech, Jay E Brenman, Ana Brennand, Emery H Bresnick, Patrick Brest, Dave Bridges, Molly L Bristol, Paul S Brookes, Eric J Brown, John H Brumell, Nicola Brunetti-Pierri, Ulf T Brunk, Dennis E Bulman, Scott J Bultman, Geert Bultynck, Lena F Burbulla, Wilfried Bursch, Jonathan P Butchar, Wanda Buzgariu, Sergio P Bydlowski, Ken Cadwell, Monika Cahová, Dongsheng Cai, Jiyang Cai, Qian Cai, Bruno Calabretta, Javier Calvo-Garrido, Nadine Camougrand, Michelangelo Campanella, Jenny Campos-Salinas, Eleonora Candi, Lizhi Cao, Allan B Caplan, Simon R Carding, Sandra M Cardoso, Jennifer S Carew, Cathleen R Carlin, Virginie Carmignac, Leticia A M Carneiro, Serena Carra, Rosario A Caruso, Giorgio Casari, Caty Casas, Roberta Castino, Eduardo Cebollero, Francesco Cecconi, Jean Celli, Hassan Chaachouay, Han-Jung Chae, Chee-Yin Chai, David C Chan, Edmond Y Chan, Raymond Chuen-Chung Chang, Chi-Ming Che, Ching-Chow Chen, Guang-Chao Chen, Guo-Qiang Chen, Min Chen, Quan Chen, Steve S-L Chen, WenLi Chen, Xi Chen, Xiangmei Chen, Xiequn Chen, Ye-Guang Chen, Yingyu Chen, Yongqiang Chen, Yu-Jen Chen, Zhixiang Chen, Alan Cheng, Christopher H K Cheng, Yan Cheng, Heesun Cheong, Jae-Ho Cheong, Sara Cherry, Russ Chess-Williams, Zelda H Cheung, Eric Chevet, Hui-Ling Chiang, Roberto Chiarelli, Tomoki Chiba, Lih-Shen Chin, Shih-Hwa Chiou, Francis V Chisari, Chi Hin Cho, Dong-Hyung Cho, Augustine M K Choi, DooSeok Choi, Kyeong Sook Choi, Mary E Choi, Salem Chouaib, Divaker Choubey, Vinay Choubey, Charleen T Chu, Tsung-Hsien Chuang, Sheau-Huei Chueh, Taehoon Chun, Yong-Joon Chwae, Mee-Len Chye, Roberto Ciarcia, Maria R Ciriolo, Michael J Clague, Robert S B Clark, Peter G H Clarke, Robert Clarke, Patrice Codogno, Hilary A Coller, María I Colombo, Sergio Comincini, Maria Condello, Fabrizio Condorelli, Mark R Cookson, Graham H Coombs, Isabelle Coppens, Ramon Corbalan, Pascale Cossart, Paola Costelli, Safia Costes, Ana Coto-Montes, Eduardo Couve, Fraser P Coxon, James M Cregg, José L Crespo, Marianne J Cronjé, Ana Maria Cuervo, Joseph J Cullen, Mark J Czaja, Marcello D'Amelio, Arlette Darfeuille-Michaud, Lester M Davids, Faith E Davies, Massimo De Felici, John F de Groot, Cornelis A M de Haan, Luisa De Martino, Angelo De Milito, Vincenzo De Tata, Jayanta Debnath, Alexei Degterev, Benjamin Dehay, Lea M D Delbridge, Francesca Demarchi, Yi Zhen Deng, Jörn Dengjel, Paul Dent, Donna Denton, Vojo Deretic, Shyamal D Desai, Rodney J Devenish, Mario Di Gioacchino, Gilbert Di Paolo, Chiara Di Pietro, Guillermo Díaz-Araya, Inés Díaz-Laviada, Maria T Diaz-Meco, Javier Diaz-Nido, Ivan Dikic, Savithramma P Dinesh-Kumar, Wen-Xing Ding, Clark W Distelhorst, Abhinav Diwan, Mojgan Djavaheri-Mergny, Svetlana Dokudovskaya, Zheng Dong, Frank C Dorsey, Victor Dosenko, James J Dowling, Stephen Doxsey, Marlène Dreux, Mark E Drew, Qiuhong Duan, Michel A Duchosal, Karen Duff, Isabelle Dugail, Madeleine Durbeej, Michael Duszenko, Charles L Edelstein, Aimee L Edinger, Gustavo Egea, Ludwig Eichinger, N Tony Eissa, Suhendan Ekmekcioglu, Wafik S El-Deiry, Zvulun Elazar, Mohamed Elgendy, Lisa M Ellerby, Kai Er Eng, Anna-Mart Engelbrecht, Simone Engelender, Jekaterina Erenpreisa, Ricardo Escalante, Audrey Esclatine, Eeva-Liisa Eskelinen, Lucile Espert, Virginia Espina, Huizhou Fan, Jia Fan, Qi-Wen Fan, Zhen Fan, Shengyun Fang, Yongqi Fang, Manolis Fanto, Alessandro Fanzani, Thomas Farkas, Jean-Claude Farré, Mathias Faure, Marcus Fechheimer, Carl G Feng, Jian Feng, Qili Feng, Youji Feng, László Fésüs, Ralph Feuer, Maria E Figueiredo-Pereira, Gian Maria Fimia, Diane C Fingar, Steven Finkbeiner, Toren Finkel, Kim D Finley, Filomena Fiorito, Edward A Fisher, Paul B Fisher, Marc Flajolet, Maria L Florez-McClure, Salvatore Florio, Edward A Fon, Francesco Fornai, Franco Fortunato, Rati Fotedar, Daniel H Fowler, Howard S Fox, Rodrigo Franco, Lisa B Frankel, Marc Fransen, José M Fuentes, Juan Fueyo, Jun Fujii, Kozo Fujisaki, Eriko Fujita, Mitsunori Fukuda, Ruth H Furukawa, Matthias Gaestel, Philippe Gailly, Malgorzata Gajewska, Brigitte Galliot, Vincent Galy, Subramaniam Ganesh, Barry Ganetzky, Ian G Ganley, Fen-Biao Gao, George F Gao, Jinming Gao, Lorena Garcia, Guillermo Garcia-Manero, Mikel Garcia-Marcos, Marjan Garmyn, Andrei L Gartel, Evelina Gatti, Mathias Gautel, Thomas R Gawriluk, Matthew E Gegg, Jiefei Geng, Marc Germain, Jason E Gestwicki, David A Gewirtz, Saeid Ghavami, Pradipta Ghosh, Anna M Giammarioli, Alexandra N Giatromanolaki, Spencer B Gibson, Robert W Gilkerson, Michael L Ginger, Henry N Ginsberg, Jakub Golab, Michael S Goligorsky, Pierre Golstein, Candelaria Gomez-Manzano, Ebru Goncu, Céline Gongora, Claudio D Gonzalez, Ramon Gonzalez, Cristina González-Estévez, Rosa Ana González-Polo, Elena Gonzalez-Rey, Nikolai V Gorbunov, Sharon Gorski, Sandro Goruppi, Roberta A Gottlieb, Devrim Gozuacik, Giovanna Elvira Granato, Gary D Grant, Kim N Green, Aleš Gregorc, Frédéric Gros, Charles Grose, Thomas W Grunt, Philippe Gual, Jun-Lin Guan, Kun-Liang Guan, Sylvie M Guichard, Anna S Gukovskaya, Ilya Gukovsky, Jan Gunst, Asa B Gustafsson, Andrew J Halayko, Amber N Hale, Sandra K Halonen, Maho Hamasaki, Feng Han, Ting Han, Michael K Hancock, Malene Hansen, Hisashi Harada, Masaru Harada, Stefan E Hardt, J Wade Harper, Adrian L Harris, James Harris, Steven D Harris, Makoto Hashimoto, Jeffrey A Haspel, Shin-ichiro Hayashi, Lori A Hazelhurst, Congcong He, You-Wen He, Marie-Joseé Hébert, Kim A Heidenreich, Miep H Helfrich, Gudmundur V Helgason, Elizabeth P Henske, Brian Herman, Paul K Herman, Claudio Hetz, Sabine Hilfiker, Joseph A Hill, Lynne J Hocking, Paul Hofman, Thomas G Hofmann, Jörg Höhfeld, Tessa L Holyoake, Ming-Huang Hong, David A Hood, Gökhan S Hotamisligil, Ewout J Houwerzijl, Maria Høyer-Hansen, Bingren Hu, Chien-An A Hu, Hong-Ming Hu, Ya Hua, Canhua Huang, Ju Huang, Shengbing Huang, Wei-Pang Huang, Tobias B Huber, Won-Ki Huh, Tai-Ho Hung, Ted R Hupp, Gang Min Hur, James B Hurley, Sabah N A Hussain, Patrick J Hussey, Jung Jin Hwang, Seungmin Hwang, Atsuhiro Ichihara, Shirin Ilkhanizadeh, Ken Inoki, Takeshi Into, Valentina Iovane, Juan L Iovanna, Nancy Y Ip, Yoshitaka Isaka, Hiroyuki Ishida, Ciro Isidoro, Ken-ichi Isobe, Akiko Iwasaki, Marta Izquierdo, Yotaro Izumi, Panu M Jaakkola, Marja Jäättelä, George R Jackson, William T Jackson, Bassam Janji, Marina Jendrach, Ju-Hong Jeon, Eui-Bae Jeung, Hong Jiang, Hongchi Jiang, Jean X Jiang, Ming Jiang, Qing Jiang, Xuejun Jiang, Xuejun Jiang, Alberto Jiménez, Meiyan Jin, Shengkan Jin, Cheol O Joe, Terje Johansen, Daniel E Johnson, Gail V W Johnson, Nicola L Jones, Bertrand Joseph, Suresh K Joseph, Annie M Joubert, Gábor Juhász, Lucienne Juillerat-Jeanneret, Chang Hwa Jung, Yong-Keun Jung, Kai Kaarniranta, Allen Kaasik, Tomohiro Kabuta, Motoni Kadowaki, Katarina Kagedal, Yoshiaki Kamada, Vitaliy O Kaminskyy, Harm H Kampinga, Hiromitsu Kanamori, Chanhee Kang, Khong Bee Kang, Kwang Il Kang, Rui Kang, Yoon-A Kang, Tomotake Kanki, Thirumala-Devi Kanneganti, Haruo Kanno, Anumantha G Kanthasamy, Arthi Kanthasamy, Vassiliki Karantza, Gur P Kaushal, Susmita Kaushik, Yoshinori Kawazoe, Po-Yuan Ke, John H Kehrl, Ameeta Kelekar, Claus Kerkhoff, David H Kessel, Hany Khalil, Jan A K W Kiel, Amy A Kiger, Akio Kihara, Deok Ryong Kim, Do-Hyung Kim, Dong-Hou Kim, Eun-Kyoung Kim, Hyung-Ryong Kim, Jae-Sung Kim, Jeong Hun Kim, Jin Cheon Kim, John K Kim, Peter K Kim, Seong Who Kim, Yong-Sun Kim, Yonghyun Kim, Adi Kimchi, Alec C Kimmelman, Jason S King, Timothy J Kinsella, Vladimir Kirkin, Lorrie A Kirshenbaum, Katsuhiko Kitamoto, Kaio Kitazato, Ludger Klein, Walter T Klimecki, Jochen Klucken, Erwin Knecht, Ben C B Ko, Jan C Koch, Hiroshi Koga, Jae-Young Koh, Young Ho Koh, Masato Koike, Masaaki Komatsu, Eiki Kominami, Hee Jeong Kong, Wei-Jia Kong, Viktor I Korolchuk, Yaichiro Kotake, Michael I Koukourakis, Juan B Kouri Flores, Attila L Kovács, Claudine Kraft, Dimitri Krainc, Helmut Krämer, Carole Kretz-Remy, Anna M Krichevsky, Guido Kroemer, Rejko Krüger, Oleg Krut, Nicholas T Ktistakis, Chia-Yi Kuan, Roza Kucharczyk, Ashok Kumar, Raj Kumar, Sharad Kumar, Mondira Kundu, Hsing-Jien Kung, Tino Kurz, Ho Jeong Kwon, Albert R La Spada, Frank Lafont, Trond Lamark, Jacques Landry, Jon D Lane, Pierre Lapaquette, Jocelyn F Laporte, Lajos László, Sergio Lavandero, Josée N Lavoie, Robert Layfield, Pedro A Lazo, Weidong Le, Laurent Le Cam, Daniel J Ledbetter, Alvin J X Lee, Byung-Wan Lee, Gyun Min Lee, Jongdae Lee, Ju-Hyun Lee, Michael Lee, Myung-Shik Lee, Sug Hyung Lee, Christiaan Leeuwenburgh, Patrick Legembre, Renaud Legouis, Michael Lehmann, Huan-Yao Lei, Qun-Ying Lei, David A Leib, José Leiro, John J Lemasters, Antoinette Lemoine, Maciej S Lesniak, Dina Lev, Victor V Levenson, Beth Levine, Efrat Levy, Faqiang Li, Jun-Lin Li, Lian Li, Sheng Li, Weijie Li, Xue-Jun Li, Yan-bo Li, Yi-Ping Li, Chengyu Liang, Qiangrong Liang, Yung-Feng Liao, Pawel P Liberski, Andrew Lieberman, Hyunjung J Lim, Kah-Leong Lim, Kyu Lim, Chiou-Feng Lin, Fu-Cheng Lin, Jian Lin, Jiandie D Lin, Kui Lin, Wan-Wan Lin, Weei-Chin Lin, Yi-Ling Lin, Rafael Linden, Paul Lingor, Jennifer Lippincott-Schwartz, Michael P Lisanti, Paloma B Liton, Bo Liu, Chun-Feng Liu, Kaiyu Liu, Leyuan Liu, Qiong A Liu, Wei Liu, Young-Chau Liu, Yule Liu, Richard A Lockshin, Chun-Nam Lok, Sagar Lonial, Benjamin Loos, Gabriel Lopez-Berestein, Carlos López-Otín, Laura Lossi, Michael T Lotze, Peter Lőw, Binfeng Lu, Bingwei Lu, Bo Lu, Zhen Lu, Frédéric Luciano, Nicholas W Lukacs, Anders H Lund, Melinda A Lynch-Day, Yong Ma, Fernando Macian, Jeff P MacKeigan, Kay F Macleod, Frank Madeo, Luigi Maiuri, Maria Chiara Maiuri, Davide Malagoli, May Christine V Malicdan, Walter Malorni, Na Man, Eva-Maria Mandelkow, Stéphen Manon, Irena Manov, Kai Mao, Xiang Mao, Zixu Mao, Philippe Marambaud, Daniela Marazziti, Yves L Marcel, Katie Marchbank, Piero Marchetti, Stefan J Marciniak, Mateus Marcondes, Mohsen Mardi, Gabriella Marfe, Guillermo Mariño, Maria Markaki, Mark R Marten, Seamus J Martin, Camille Martinand-Mari, Wim Martinet, Marta Martinez-Vicente, Matilde Masini, Paola Matarrese, Saburo Matsuo, Raffaele Matteoni, Andreas Mayer, Nathalie M Mazure, David J McConkey, Melanie J McConnell, Catherine McDermott, Christine McDonald, Gerald M McInerney, Sharon L McKenna, BethAnn McLaughlin, Pamela J McLean, Christopher R McMaster, G Angus McQuibban, Alfred J Meijer, Miriam H Meisler, Alicia Meléndez, Thomas J Melia, Gerry Melino, Maria A Mena, Javier A Menendez, Rubem F S Menna-Barreto, Manoj B Menon, Fiona M Menzies, Carol A Mercer, Adalberto Merighi, Diane E Merry, Stefania Meschini, Christian G Meyer, Thomas F Meyer, Chao-Yu Miao, Jun-Ying Miao, Paul A M Michels, Carine Michiels, Dalibor Mijaljica, Ana Milojkovic, Saverio Minucci, Clelia Miracco, Cindy K Miranti, Ioannis Mitroulis, Keisuke Miyazawa, Noboru Mizushima, Baharia Mograbi, Simin Mohseni, Xavier Molero, Bertrand Mollereau, Faustino Mollinedo, Takashi Momoi, Iryna Monastyrska, Martha M Monick, Mervyn J Monteiro, Michael N Moore, Rodrigo Mora, Kevin Moreau, Paula I Moreira, Yuji Moriyasu, Jorge Moscat, Serge Mostowy, Jeremy C Mottram, Tomasz Motyl, Charbel E-H Moussa, Sylke Müller, Sylviane Muller, Karl Münger, Christian Münz, Leon O Murphy, Maureen E Murphy, Antonio Musarò, Indira Mysorekar, Eiichiro Nagata, Kazuhiro Nagata, Aimable Nahimana, Usha Nair, Toshiyuki Nakagawa, Kiichi Nakahira, Hiroyasu Nakano, Hitoshi Nakatogawa, Meera Nanjundan, Naweed I Naqvi, Derek P Narendra, Masashi Narita, Miguel Navarro, Steffan T Nawrocki, Taras Y Nazarko, Andriy Nemchenko, Mihai G Netea, Thomas P Neufeld, Paul A Ney, Ioannis P Nezis, Huu Phuc Nguyen, Daotai Nie, Ichizo Nishino, Corey Nislow, Ralph A Nixon, Takeshi Noda, Angelika A Noegel, Anna Nogalska, Satoru Noguchi, Lucia Notterpek, Ivana Novak, Tomoyoshi Nozaki, Nobuyuki Nukina, Thorsten Nürnberger, Beat Nyfeler, Keisuke Obara, Terry D Oberley, Salvatore Oddo, Michinaga Ogawa, Toya Ohashi, Koji Okamoto, Nancy L Oleinick, F Javier Oliver, Laura J Olsen, Stefan Olsson, Onya Opota, Timothy F Osborne, Gary K Ostrander, Kinya Otsu, Jing-hsiung James Ou, Mireille Ouimet, Michael Overholtzer, Bulent Ozpolat, Paolo Paganetti, Ugo Pagnini, Nicolas Pallet, Glen E Palmer, Camilla Palumbo, Tianhong Pan, Theocharis Panaretakis, Udai Bhan Pandey, Zuzana Papackova, Issidora Papassideri, Irmgard Paris, Junsoo Park, Ohkmae K Park, Jan B Parys, Katherine R Parzych, Susann Patschan, Cam Patterson, Sophie Pattingre, John M Pawelek, Jianxin Peng, David H Perlmutter, Ida Perrotta, George Perry, Shazib Pervaiz, Matthias Peter, Godefridus J Peters, Morten Petersen, Goran Petrovski, James M Phang, Mauro Piacentini, Philippe Pierre, Valérie Pierrefite-Carle, Gérard Pierron, Ronit Pinkas-Kramarski, Antonio Piras, Natik Piri, Leonidas C Platanias, Stefanie Pöggeler, Marc Poirot, Angelo Poletti, Christian Poüs, Mercedes Pozuelo-Rubio, Mette Prætorius-Ibba, Anil Prasad, Mark Prescott, Muriel Priault, Nathalie Produit-Zengaffinen, Ann Progulske-Fox, Tassula Proikas-Cezanne, Serge Przedborski, Karin Przyklenk, Rosa Puertollano, Julien Puyal, Shu-Bing Qian, Liang Qin, Zheng-Hong Qin, Susan E Quaggin, Nina Raben, Hannah Rabinowich, Simon W Rabkin, Irfan Rahman, Abdelhaq Rami, Georg Ramm, Glenn Randall, Felix Randow, V Ashutosh Rao, Jeffrey C Rathmell, Brinda Ravikumar, Swapan K Ray, Bruce H Reed, John C Reed, Fulvio Reggiori, Anne Régnier-Vigouroux, Andreas S Reichert, John J Reiners, Russel J Reiter, Jun Ren, José L Revuelta, Christopher J Rhodes, Konstantinos Ritis, Elizete Rizzo, Jeffrey Robbins, Michel Roberge, Hernan Roca, Maria C Roccheri, Stephane Rocchi, H Peter Rodemann, Santiago Rodríguez de Córdoba, Bärbel Rohrer, Igor B Roninson, Kirill Rosen, Magdalena M Rost-Roszkowska, Mustapha Rouis, Kasper M A Rouschop, Francesca Rovetta, Brian P Rubin, David C Rubinsztein, Klaus Ruckdeschel, Edmund B Rucker, Assaf Rudich, Emil Rudolf, Nelson Ruiz-Opazo, Rossella Russo, Tor Erik Rusten, Kevin M Ryan, Stefan W Ryter, David M Sabatini, Junichi Sadoshima, Tapas Saha, Tatsuya Saitoh, Hiroshi Sakagami, Yasuyoshi Sakai, Ghasem Hoseini Salekdeh, Paolo Salomoni, Paul M Salvaterra, Guy Salvesen, Rosa Salvioli, Anthony M J Sanchez, José A Sánchez-Alcázar, Ricardo Sánchez-Prieto, Marco Sandri, Uma Sankar, Poonam Sansanwal, Laura Santambrogio, Shweta Saran, Sovan Sarkar, Minnie Sarwal, Chihiro Sasakawa, Ausra Sasnauskiene, Miklós Sass, Ken Sato, Miyuki Sato, Anthony H V Schapira, Michael Scharl, Hermann M Schätzl, Wiep Scheper, Stefano Schiaffino, Claudio Schneider, Marion E Schneider, Regine Schneider-Stock, Patricia V Schoenlein, Daniel F Schorderet, Christoph Schüller, Gary K Schwartz, Luca Scorrano, Linda Sealy, Per O Seglen, Juan Segura-Aguilar, Iban Seiliez, Oleksandr Seleverstov, Christian Sell, Jong Bok Seo, Duska Separovic, Vijayasaradhi Setaluri, Takao Setoguchi, Carmine Settembre, John J Shacka, Mala Shanmugam, Irving M Shapiro, Eitan Shaulian, Reuben J Shaw, James H Shelhamer, Han-Ming Shen, Wei-Chiang Shen, Zu-Hang Sheng, Yang Shi, Kenichi Shibuya, Yoshihiro Shidoji, Jeng-Jer Shieh, Chwen-Ming Shih, Yohta Shimada, Shigeomi Shimizu, Takahiro Shintani, Orian S Shirihai, Gordon C Shore, Andriy A Sibirny, Stan B Sidhu, Beata Sikorska, Elaine C M Silva-Zacarin, Alison Simmons, Anna Katharina Simon, Hans-Uwe Simon, Cristiano Simone, Anne Simonsen, David A Sinclair, Rajat Singh, Debasish Sinha, Frank A Sinicrope, Agnieszka Sirko, Parco M Siu, Efthimios Sivridis, Vojtech Skop, Vladimir P Skulachev, Ruth S Slack, Soraya S Smaili, Duncan R Smith, Maria S Soengas, Thierry Soldati, Xueqin Song, Anil K Sood, Tuck Wah Soong, Federica Sotgia, Stephen A Spector, Claudia D Spies, Wolfdieter Springer, Srinivasa M Srinivasula, Leonidas Stefanis, Joan S Steffan, Ruediger Stendel, Harald Stenmark, Anastasis Stephanou, Stephan T Stern, Cinthya Sternberg, Björn Stork, Peter Strålfors, Carlos S Subauste, Xinbing Sui, David Sulzer, Jiaren Sun, Shi-Yong Sun, Zhi-Jun Sun, Joseph J Y Sung, Kuninori Suzuki, Toshihiko Suzuki, Michele S Swanson, Charles Swanton, Sean T Sweeney, Lai-King Sy, Gyorgy Szabadkai, Ira Tabas, Heinrich Taegtmeyer, Marco Tafani, Krisztina Takács-Vellai, Yoshitaka Takano, Kaoru Takegawa, Genzou Takemura, Fumihiko Takeshita, Nicholas J Talbot, Kevin S W Tan, Keiji Tanaka, Kozo Tanaka, Daolin Tang, Dingzhong Tang, Isei Tanida, Bakhos A Tannous, Nektarios Tavernarakis, Graham S Taylor, Gregory A Taylor, J Paul Taylor, Lance S Terada, Alexei Terman, Gianluca Tettamanti, Karin Thevissen, Craig B Thompson, Andrew Thorburn, Michael Thumm, FengFeng Tian, Yuan Tian, Glauco Tocchini-Valentini, Aviva M Tolkovsky, Yasuhiko Tomino, Lars Tönges, Sharon A Tooze, Cathy Tournier, John Tower, Roberto Towns, Vladimir Trajkovic, Leonardo H Travassos, Ting-Fen Tsai, Mario P Tschan, Takeshi Tsubata, Allan Tsung, Boris Turk, Lorianne S Turner, Suresh C Tyagi, Yasuo Uchiyama, Takashi Ueno, Midori Umekawa, Rika Umemiya-Shirafuji, Vivek K Unni, Maria I Vaccaro, Enza Maria Valente, Greet Van den Berghe, Ida J van der Klei, Wouter van Doorn, Linda F van Dyk, Marjolein van Egmond, Leo A van Grunsven, Peter Vandenabeele, Wim P Vandenberghe, Ilse Vanhorebeek, Eva C Vaquero, Guillermo Velasco, Tibor Vellai, Jose Miguel Vicencio, Richard D Vierstra, Miquel Vila, Cécile Vindis, Giampietro Viola, Maria Teresa Viscomi, Olga V Voitsekhovskaja, Clarissa von Haefen, Marcela Votruba, Keiji Wada, Richard Wade-Martins, Cheryl L Walker, Craig M Walsh, Jochen Walter, Xiang-Bo Wan, Aimin Wang, Chenguang Wang, Dawei Wang, Fan Wang, Fen Wang, Guanghui Wang, Haichao Wang, Hong-Gang Wang, Horng-Dar Wang, Jin Wang, Ke Wang, Mei Wang, Richard C Wang, Xinglong Wang, Xuejun Wang, Ying-Jan Wang, Yipeng Wang, Zhen Wang, Zhigang Charles Wang, Zhinong Wang, Derick G Wansink, Diane M Ward, Hirotaka Watada, Sarah L Waters, Paul Webster, Lixin Wei, Conrad C Weihl, William A Weiss, Scott M Welford, Long-Ping Wen, Caroline A Whitehouse, J Lindsay Whitton, Alexander J Whitworth, Tom Wileman, John W Wiley, Simon Wilkinson, Dieter Willbold, Roger L Williams, Peter R Williamson, Bradly G Wouters, Chenghan Wu, Dao-Cheng Wu, William K K Wu, Andreas Wyttenbach, Ramnik J Xavier, Zhijun Xi, Pu Xia, Gengfu Xiao, Zhiping Xie, Zhonglin Xie, Da-zhi Xu, Jianzhen Xu, Liang Xu, Xiaolei Xu, Ai Yamamoto, Akitsugu Yamamoto, Shunhei Yamashina, Michiaki Yamashita, Xianghua Yan, Mitsuhiro Yanagida, Dun-Sheng Yang, Elizabeth Yang, Jin-Ming Yang, Shi Yu Yang, Wannian Yang, Wei Yuan Yang, Zhifen Yang, Meng-Chao Yao, Tso-Pang Yao, Behzad Yeganeh, Wei-Lien Yen, Jia-jing Yin, Xiao-Ming Yin, Ook-Joon Yoo, Gyesoon Yoon, Seung-Yong Yoon, Tomohiro Yorimitsu, Yuko Yoshikawa, Tamotsu Yoshimori, Kohki Yoshimoto, Ho Jin You, Richard J Youle, Anas Younes, Li Yu, Long Yu, Seong-Woon Yu, Wai Haung Yu, Zhi-Min Yuan, Zhenyu Yue, Cheol-Heui Yun, Michisuke Yuzaki, Olga Zabirnyk, Elaine Silva-Zacarin, David Zacks, Eldad Zacksenhaus, Nadia Zaffaroni, Zahra Zakeri, Herbert J Zeh, Scott O Zeitlin, Hong Zhang, Hui-Ling Zhang, Jianhua Zhang, Jing-Pu Zhang, Lin Zhang, Long Zhang, Ming-Yong Zhang, Xu Dong Zhang, Mantong Zhao, Yi-Fang Zhao, Ying Zhao, Zhizhuang J Zhao, Xiaoxiang Zheng, Boris Zhivotovsky, Qing Zhong, Cong-Zhao Zhou, Changlian Zhu, Wei-Guo Zhu, Xiao-Feng Zhu, Xiongwei Zhu, Yuangang Zhu, Teresa Zoladek, Wei-Xing Zong, Antonio Zorzano, Jürgen Zschocke, Brian Zuckerbraun

PMID:22966490


Receptor proteins in selective autophagy

Int J Cell Biol. 2012;2012:673290. doi: 10.1155/2012/673290. Epub 2012 Mar 20.

Authors: Christian Behrends, Simone Fulda

PMID:22536250


Rab GTPase-activating proteins in autophagy: regulation of endocytic and autophagy pathways by direct binding to human ATG8 modifiers

Mol Cell Biol. 2012 May;32(9):1733-44. doi: 10.1128/MCB.06717-11. Epub 2012 Feb 21.

Authors: Doris Popovic, Masato Akutsu, Ivana Novak, J Wade Harper, Christian Behrends, Ivan Dikic

PMID:22354992


Constructing and decoding unconventional ubiquitin chains

Nat Struct Mol Biol. 2011 May;18(5):520-8. doi: 10.1038/nsmb.2066.

Authors: Christian Behrends, J Wade Harper

PMID:21540891


Network organization of the human autophagy system

Nature. 2010 Jul 1;466(7302):68-76. doi: 10.1038/nature09204. Epub 2010 Jun 20.

Authors: Christian Behrends, Mathew E Sowa, Steven P Gygi, J Wade Harper

PMID:20562859


Chaperonin TRiC promotes the assembly of polyQ expansion proteins into nontoxic oligomers

Mol Cell. 2006 Sep 15;23(6):887-97. doi: 10.1016/j.molcel.2006.08.017.

Authors: Christian Behrends, Carola A Langer, Raina Boteva, Ulrike M Böttcher, Markus J Stemp, Gregor Schaffar, Bharathi Vasudeva Rao, Armin Giese, Hans Kretzschmar, Katja Siegers, F Ulrich Hartl

PMID:16973440


Characterization of presenilin-amyloid precursor interaction using bacterial expression and two-hybrid systems for human membrane proteins

Mol Membr Biol. 2004 Nov-Dec;21(6):373-83. doi: 10.1080/09687860400008429.

Authors: Mona Harnasch, Sandra Grau, Christian Behrends, Simon L Dove, Ann Hochschild, Maria-Karnina Iskandar, Weiming Xia, Michael Ehrmann

PMID:15764367


Cellular toxicity of polyglutamine expansion proteins: mechanism of transcription factor deactivation

Mol Cell. 2004 Jul 2;15(1):95-105. doi: 10.1016/j.molcel.2004.06.029.

Authors: Gregor Schaffar, Peter Breuer, Raina Boteva, Christian Behrends, Nikolay Tzvetkov, Nadine Strippel, Hideki Sakahira, Katja Siegers, Manajit Hayer-Hartl, F Ulrich Hartl

PMID:15225551