AMPK is activated during lysosomal damage via a galectin-ubiquitin signal transduction system

Jia J, et al. Autophagy 2020. Among authors: Behrends C.

Authors: Jingyue Jia, Bhawana Bissa, Lukas Brecht, Lee Allers, Seong Won Choi, Yuexi Gu, Mark Zbinden, Mark R Burge, Graham Timmins, Kenneth Hallows, Christian Behrends, Vojo Deretic

PMID:32597364


The GABARAP Co-Secretome Identified by APEX2-GABARAP Proximity Labelling of Extracellular Vesicles

Sanwald JL, et al. Cells 2020. Among authors: Behrends C.

Authors: Julia L Sanwald, Gereon Poschmann, Kai Stühler, Christian Behrends, Silke Hoffmann, Dieter Willbold

PMID:32560054


NRBF2 is a RAB7 effector required for autophagosome maturation and mediates the association of APP-CTFs with active form of RAB7 for degradation

Cai CZ, et al. Autophagy 2020. Among authors: Behrends C.

Authors: Cui-Zan Cai, Chuanbin Yang, Xu-Xu Zhuang, Ning-Ning Yuan, Ming-Yue Wu, Jie-Qiong Tan, Ju-Xian Song, King-Ho Cheung, Huanxing Su, Yi-Tao Wang, Bei-Sha Tang, Christian Behrends, Siva Sundara Kumar Durairajan, Zhenyu Yue, Min Li, Jia-Hong Lu

PMID:32543313


When Separation Causes Activation: Biophysical Control of Bulk Autophagy Initiation

Bhattacharya D and Behrends C. Mol Cell 2020.

Authors: Debjani Bhattacharya, Christian Behrends

PMID:32386541


AMPK, a Regulator of Metabolism and Autophagy, Is Activated by Lysosomal Damage via a Novel Galectin-Directed Ubiquitin Signal Transduction System

Jia J, et al. Mol Cell 2020. Among authors: Behrends C.

Authors: Jingyue Jia, Bhawana Bissa, Lukas Brecht, Lee Allers, Seong Won Choi, Yuexi Gu, Mark Zbinden, Mark R Burge, Graham Timmins, Kenneth Hallows, Christian Behrends, Vojo Deretic

PMID:31995728


Molecular Mechanisms of Selective Autophagy

Martens S and Behrends C. J Mol Biol 2020.

Authors: Sascha Martens, Christian Behrends

PMID:31839401


Regulation of lysosome integrity and lysophagy by the ubiquitin-conjugating enzyme UBE2QL1

Kravic B, et al. Autophagy 2020. Among authors: Behrends C.

Authors: Bojana Kravic, Christian Behrends, Hemmo Meyer

PMID:31679434


The ubiquitin-conjugating enzyme UBE2QL1 coordinates lysophagy in response to endolysosomal damage

Koerver L, et al. EMBO Rep 2019. Among authors: Behrends C.

Authors: Lisa Koerver, Chrisovalantis Papadopoulos, Bin Liu, Bojana Kravic, Giulia Rota, Lukas Brecht, Tineke Veenendaal, Mira Polajnar, Anika Bluemke, Michael Ehrmann, Judith Klumperman, Marja Jäättelä, Christian Behrends, Hemmo Meyer

PMID:31432621


Loss of Peter Pan (PPAN) Affects Mitochondrial Homeostasis and Autophagic Flux

Dannheisig DP, et al. Cells 2019. Among authors: Behrends C.

Authors: David P Dannheisig, Eileen Beck, Enrico Calzia, Paul Walther, Christian Behrends, Astrid S Pfister

PMID:31416196


RITA modulates cell migration and invasion by affecting focal adhesion dynamics

Hoock SC, et al. Mol Oncol 2019. Among authors: Behrends C.

Authors: Samira Catharina Hoock, Andreas Ritter, Kerstin Steinhäuser, Susanne Roth, Christian Behrends, Franz Oswald, Christine Solbach, Frank Louwen, Nina-Naomi Kreis, Juping Yuan

PMID:31353815


Increased Immune Activation by Pathologic α-Synuclein in Parkinson's Disease

Grozdanov V, et al. Ann Neurol 2019. Among authors: Behrends C.

Authors: Veselin Grozdanov, Luc Bousset, Meike Hoffmeister, Corinna Bliederhaeuser, Christoph Meier, Karine Madiona, Laura Pieri, Martin Kiechle, Pamela J McLean, Jan Kassubek, Christian Behrends, Albert C Ludolph, Jochen H Weishaupt, Ronald Melki, Karin M Danzer

PMID:31343083


The Hippo network kinase STK38 contributes to protein homeostasis by inhibiting BAG3-mediated autophagy

Klimek C, et al. Biochim Biophys Acta Mol Cell Res 2019. Among authors: Behrends C.

Authors: Christina Klimek, Ricarda Jahnke, Judith Wördehoff, Barbara Kathage, Daniela Stadel, Christian Behrends, Alexander Hergovich, Jörg Höhfeld

PMID:31326538


Autophagy, Inflammation, and Metabolism (AIM) Center in its second year

Deretic V, et al. Autophagy 2019. Among authors: Behrends C.

Authors: Vojo Deretic, Eric Prossnitz, Mark Burge, Matthew J Campen, Judy Cannon, Ke Jian Liu, Meilian Liu, Pamela Hall, Larry A Sklar, Lee Allers, Luisa Mariscal, Sally Ann Garcia, John Weaver, Eric H Baehrecke, Christian Behrends, Francesco Cecconi, Patrice Codogno, Guang-Chao Chen, Zvulun Elazar, Eeva-Liisa Eskelinen, Bernard Fourie, Devrim Gozuacik, Wanjin Hong, Eun-Kyeong Jo, Terje Johansen, Gábor Juhász, Adi Kimchi, Nicholas Ktistakis, Guido Kroemer, Noboru Mizushima, Christian Münz, Fulvio Reggiori, David Rubinsztein, Kevin Ryan, Kate Schroder, Han-Min Shen, Anne Simonsen, Sharon A Tooze, Maria Vaccaro, Tamotsu Yoshimori, Li Yu, Hong Zhang, Daniel J Klionsky

PMID:31234750


LTK is an ER-resident receptor tyrosine kinase that regulates secretion

Centonze FG, et al. J Cell Biol 2019. Among authors: Behrends C.

Authors: Federica G Centonze, Veronika Reiterer, Karsten Nalbach, Kota Saito, Krzysztof Pawlowski, Christian Behrends, Hesso Farhan

PMID:31227593


Glia-specific autophagy dysfunction in ALS

Strohm L and Behrends C. Semin Cell Dev Biol 2020 - Review.

Authors: Laura Strohm, Christian Behrends

PMID:31132469


Regulation of death receptor signaling by the autophagy protein TP53INP2

Ivanova S, et al. EMBO J 2019. Among authors: Behrends C.

Authors: Saška Ivanova, Mira Polajnar, Alvaro Jesus Narbona-Perez, Maria Isabel Hernandez-Alvarez, Petra Frager, Konstantin Slobodnyuk, Natalia Plana, Angel R Nebreda, Manuel Palacin, Roger R Gomis, Christian Behrends, Antonio Zorzano

PMID:30979779


Lysosomal targeting of the ABC transporter TAPL is determined by membrane-localized charged residues

Graab P, et al. J Biol Chem 2019. Among authors: Behrends C.

Authors: Philipp Graab, Christoph Bock, Konstantin Weiss, Alexander Hirth, Nicole Koller, Markus Braner, Jennifer Jung, Frank Loehr, Robert Tampé, Christian Behrends, Rupert Abele

PMID:30877195


Multiple molecular pathways stimulating macroautophagy protect from alpha-synuclein-induced toxicity in human neurons

Höllerhage M, et al. Neuropharmacology 2019. Among authors: Behrends C.

Authors: Matthias Höllerhage, Natascha Fussi, Thomas W Rösler, Wolfgang Wurst, Christian Behrends, Günter U Höglinger

PMID:30731136


Loss of the selective autophagy receptor p62 impairs murine myeloid leukemia progression and mitophagy

Nguyen TD, et al. Blood 2019. Among authors: Behrends C.

Authors: The Duy Nguyen, Shabnam Shaid, Olesya Vakhrusheva, Sebastian E Koschade, Kevin Klann, Marlyn Thölken, Fatima Baker, Jing Zhang, Thomas Oellerich, Duran Sürün, Anja Derlet, Isabella Haberbosch, Stefan Eimer, Heinz D Osiewacz, Christian Behrends, Christian Münch, Ivan Dikic, Christian H Brandts

PMID:30498063


Exosomal secretion of α-synuclein as protective mechanism after upstream blockage of macroautophagy

Fussi N, et al. Cell Death Dis 2018. Among authors: Behrends C.

Authors: Natascha Fussi, Matthias Höllerhage, Tasnim Chakroun, Niko-Petteri Nykänen, Thomas W Rösler, Thomas Koeglsperger, Wolfgang Wurst, Christian Behrends, Günter U Höglinger

PMID:29988147


Cellular Mechanisms Controlling Surfacing of AICL Glycoproteins, Cognate Ligands of the Activating NK Receptor NKp80

Neuss S, et al. J Immunol 2018. Among authors: Behrends C.

Authors: Sebastian Neuss, Yvonne Bartel, Christina Born, Sandra Weil, Joachim Koch, Christian Behrends, Meike Hoffmeister, Alexander Steinle

PMID:29980609


Autophagy, Inflammation, and Metabolism (AIM) Center of Biomedical Research Excellence: supporting the next generation of autophagy researchers and fostering international collaborations

Deretic V, et al. Autophagy 2018. Among authors: Behrends C.

Authors: Vojo Deretic, Eric Prossnitz, Mark Burge, Matthew J Campen, Judy Cannon, Ke Jian Liu, Larry A Sklar, Lee Allers, Sally Ann Garcia, Eric H Baehrecke, Christian Behrends, Francesco Cecconi, Patrice Codogno, Guang-Chao Chen, Zvulun Elazar, Eeva-Liisa Eskelinen, Bernard Fourie, Devrim Gozuacik, Wanjin Hong, Gokhan Hotamisligi, Marja Jäättelä, Eun-Kyeong Jo, Terje Johansen, Gábor Juhász, Adi Kimchi, Nicholas Ktistakis, Guido Kroemer, Noboru MIzushima, Christian Münz, Fulvio Reggiori, David Rubinsztein, Kevin Ryan, Kate Schroder, Anne Simonsen, Sharon Tooze, Maria I Vaccaro, Tamotsu Yoshimori, Li Yu, Hong Zhang, Daniel J Klionsky

PMID:29938597


AT 101 induces early mitochondrial dysfunction and HMOX1 (heme oxygenase 1) to trigger mitophagic cell death in glioma cells

Meyer N, et al. Autophagy 2018. Among authors: Behrends C.

Authors: Nina Meyer, Svenja Zielke, Jonas B Michaelis, Benedikt Linder, Verena Warnsmann, Stefanie Rakel, Heinz D Osiewacz, Simone Fulda, Michel Mittelbronn, Christian Münch, Christian Behrends, Donat Kögel

PMID:29938581


Arginine Methylation Regulates MEIS2 Nuclear Localization to Promote Neuronal Differentiation of Adult SVZ Progenitors

Kolb J, et al. Stem Cell Reports 2018. Among authors: Behrends C.

Authors: Jasmine Kolb, Marie Anders-Maurer, Tanja Müller, Ann-Christin Hau, Britta Moyo Grebbin, Wiebke Kallenborn-Gerhardt, Christian Behrends, Dorothea Schulte

PMID:29641989


The pseudophosphatase STYX targets the F-box of FBXW7 and inhibits SCFFBXW7 function

Reiterer V, et al. EMBO J 2018. Among authors: Behrends C.

Authors: Veronika Reiterer, Cristina Figueras-Puig, Francois Le Guerroue, Stefano Confalonieri, Manuela Vecchi, Dasaradha Jalapothu, Sandip M Kanse, Raymond J Deshaies, Pier Paolo Di Fiore, Christian Behrends, Hesso Farhan

PMID:29545456


Oocyte DNA damage quality control requires consecutive interplay of CHK2 and CK1 to activate p63

Tuppi M, et al. Nat Struct Mol Biol 2018. Among authors: Behrends C.

Authors: Marcel Tuppi, Sebastian Kehrloesser, Daniel W Coutandin, Valerio Rossi, Laura M Luh, Alexander Strubel, Katharina Hötte, Meike Hoffmeister, Birgit Schäfer, Tiago De Oliveira, Florian Greten, Ernst H K Stelzer, Stefan Knapp, Massimo De Felici, Christian Behrends, Francesca Gioia Klinger, Volker Dötsch

PMID:29483652


CCPG1 Is a Non-canonical Autophagy Cargo Receptor Essential for ER-Phagy and Pancreatic ER Proteostasis

Smith MD, et al. Dev Cell 2018. Among authors: Behrends C.

Authors: Matthew D Smith, Margaret E Harley, Alain J Kemp, Jimi Wills, Martin Lee, Mark Arends, Alex von Kriegsheim, Christian Behrends, Simon Wilkinson

PMID:29290589


Autophagosomal Content Profiling Reveals an LC3C-Dependent Piecemeal Mitophagy Pathway

Le Guerroué F, et al. Mol Cell 2017. Among authors: Behrends C.

Authors: François Le Guerroué, Franziska Eck, Jennifer Jung, Tatjana Starzetz, Michel Mittelbronn, Manuel Kaulich, Christian Behrends

PMID:29149599


Autophagy acts through TRAF3 and RELB to regulate gene expression via antagonism of SMAD proteins

Newman AC, et al. Nat Commun 2017. Among authors: Behrends C.

Authors: Alice C Newman, Alain J Kemp, Yvette Drabsch, Christian Behrends, Simon Wilkinson

PMID:29146913


Effects of soluble CPE on glioma cell migration are associated with mTOR activation and enhanced glucose flux

Ilina EI, et al. Oncotarget 2017. Among authors: Behrends C.

Authors: Elena I Ilina, Angela Armento, Leticia Garea Sanchez, Marina Reichlmeir, Yannick Braun, Cornelia Penski, David Capper, Felix Sahm, Lukas Jennewein, Patrick N Harter, Sven Zukunft, Ingrid Fleming, Dorothea Schulte, Francois Le Guerroué, Christian Behrends, Michael W Ronellenfitsch, Ulrike Naumann, Michel Mittelbronn

PMID:28978054


Protocol for Establishing a Multiplex Image-based Autophagy RNAi Screen in Cell Cultures

Jung J and Behrends C. Bio Protoc 2017.

Authors: Jennifer Jung, Christian Behrends

PMID:28966949


Phospho-Rasputin Stabilization by Sec16 Is Required for Stress Granule Formation upon Amino Acid Starvation

Aguilera-Gomez A, et al. Cell Rep 2017. Among authors: Behrends C.

Authors: Angelica Aguilera-Gomez, Margarita Zacharogianni, Marinke M van Oorschot, Heide Genau, Rianne Grond, Tineke Veenendaal, Kristina S Sinsimer, Elisabeth A Gavis, Christian Behrends, Catherine Rabouille

PMID:28854374


Site-specific inhibition of the small ubiquitin-like modifier (SUMO)-conjugating enzyme Ubc9 selectively impairs SUMO chain formation

Wiechmann S, et al. J Biol Chem 2017. Among authors: Behrends C.

Authors: Svenja Wiechmann, Anne Gärtner, Andreas Kniss, Andreas Stengl, Christian Behrends, Vladimir V Rogov, Manuel S Rodriguez, Volker Dötsch, Stefan Müller, Andreas Ernst

PMID:28784659


Expanding the host cell ubiquitylation machinery targeting cytosolic Salmonella

Polajnar M, et al. EMBO Rep 2017. Among authors: Behrends C.

Authors: Mira Polajnar, Marina S Dietz, Mike Heilemann, Christian Behrends

PMID:28784601


Phospho-Rasputin Stabilization by Sec16 Is Required for Stress Granule Formation upon Amino Acid Starvation

Aguilera-Gomez A, et al. Cell Rep 2017. Among authors: Behrends C.

Authors: Angelica Aguilera-Gomez, Margarita Zacharogianni, Marinke M van Oorschot, Heide Genau, Rianne Grond, Tineke Veenendaal, Kristina S Sinsimer, Elizabeth R Gavis, Christian Behrends, Catherine Rabouille

PMID:28746877


Multifaceted role of SMCR8 as autophagy regulator

Jung J and Behrends C. Small GTPases 2020.

Authors: Jennifer Jung, Christian Behrends

PMID:28696821


Multiplex image-based autophagy RNAi screening identifies SMCR8 as ULK1 kinase activity and gene expression regulator

Jung J, et al. Elife 2017. Among authors: Behrends C.

Authors: Jennifer Jung, Arnab Nayak, Véronique Schaeffer, Tatjana Starzetz, Achim K Kirsch, Stefan Müller, Ivan Dikic, Michel Mittelbronn, Christian Behrends

PMID:28195531


The pseudophosphatase STYX targets the F-box of FBXW7 and inhibits SCFFBXW7 function

Reiterer V, et al. EMBO J 2017. Among authors: Behrends C.

Authors: Veronika Reiterer, Cristina Figueras-Puig, Francois Le Guerroue, Stefano Confalonieri, Manuela Vecchi, Dasaradha Jalapothu, Sandip M Kanse, Raymond J Deshaies, Pier Paolo Di Fiore, Christian Behrends, Hesso Farhan

PMID:28007894


Progranulin overexpression in sensory neurons attenuates neuropathic pain in mice: Role of autophagy

Altmann C, et al. Neurobiol Dis 2016. Among authors: Behrends C.

Authors: Christine Altmann, Stefanie Hardt, Caroline Fischer, Juliana Heidler, Hee-Young Lim, Annett Häussler, Boris Albuquerque, Béla Zimmer, Christine Möser, Christian Behrends, Frank Koentgen, Ilka Wittig, Mirko H H Schmidt, Albrecht M Clement, Thomas Deller, Irmgard Tegeder

PMID:27629805


An siRNA screen for ATG protein depletion reveals the extent of the unconventional functions of the autophagy proteome in virus replication

Mauthe M, et al. J Cell Biol 2016. Among authors: Behrends C.

Authors: Mario Mauthe, Martijn Langereis, Jennifer Jung, Xingdong Zhou, Alex Jones, Wienand Omta, Sharon A Tooze, Björn Stork, Søren Riis Paludan, Tero Ahola, Dave Egan, Christian Behrends, Michal Mokry, Cornelis de Haan, Frank van Kuppeveld, Fulvio Reggiori

PMID:27573464


Unveiling ubiquitinome rearrangements induced by Salmonella infection

Bionda T and Behrends C. Autophagy 2016.

Authors: Tihana Bionda, Christian Behrends

PMID:27467224


GABARAP proteins as scaffolds in localized TIAM1-RAC1 signaling

Genau HM and Behrends C. Mol Cell Oncol 2015.

Authors: Heide Marika Genau, Christian Behrends

PMID:27308540


Global Analysis of Host and Bacterial Ubiquitinome in Response to Salmonella Typhimurium Infection

Fiskin E, et al. Mol Cell 2016. Among authors: Behrends C.

Authors: Evgenij Fiskin, Tihana Bionda, Ivan Dikic, Christian Behrends

PMID:27211868


Diagnostic and clinical relevance of the autophago-lysosomal network in human gliomas

Jennewein L, et al. Oncotarget 2016. Among authors: Behrends C.

Authors: Lukas Jennewein, Michael W Ronellenfitsch, Patrick Antonietti, Elena I Ilina, Jennifer Jung, Daniela Stadel, Lisa-Marie Flohr, Jenny Zinke, Janusz von Renesse, Ulrich Drott, Peter Baumgarten, Anne K Braczynski, Cornelia Penski, Michael C Burger, Jean-Philippe Theurillat, Joachim P Steinbach, Karl-Heinz Plate, Ivan Dikic, Simone Fulda, Christian Brandts, Donat Kögel, Christian Behrends, Patrick N Harter, Michel Mittelbronn

PMID:26956048


TBC1D14 regulates autophagy via the TRAPP complex and ATG9 traffic

Lamb CA, et al. EMBO J 2016. Among authors: Behrends C.

Authors: Christopher A Lamb, Stefanie Nühlen, Delphine Judith, David Frith, Ambrosius P Snijders, Christian Behrends, Sharon A Tooze

PMID:26711178


TECPR2 Cooperates with LC3C to Regulate COPII-Dependent ER Export

Stadel D, et al. Mol Cell 2015. Among authors: Behrends C.

Authors: Daniela Stadel, Valentina Millarte, Kerstin D Tillmann, Jessica Huber, Bat-Chen Tamin-Yecheskel, Masato Akutsu, Alik Demishtein, Bruria Ben-Zeev, Yair Anikster, Franck Perez, Volker Dötsch, Zvulun Elazar, Vladimir Rogov, Hesso Farhan, Christian Behrends

PMID:26431026


Amino Acid-Dependent mTORC1 Regulation by the Lysosomal Membrane Protein SLC38A9

Jung J, et al. Mol Cell Biol 2015. Among authors: Behrends C.

Authors: Jennifer Jung, Heide Marika Genau, Christian Behrends

PMID:25963655


CUL3-KBTBD6/KBTBD7 ubiquitin ligase cooperates with GABARAP proteins to spatially restrict TIAM1-RAC1 signaling

Genau HM, et al. Mol Cell 2015. Among authors: Behrends C.

Authors: Heide Marika Genau, Jessica Huber, Francesco Baschieri, Masato Akutsu, Volker Dötsch, Hesso Farhan, Vladimir Rogov, Christian Behrends

PMID:25684205


PLEKHM1 regulates autophagosome-lysosome fusion through HOPS complex and LC3/GABARAP proteins

McEwan DG, et al. Mol Cell 2015. Among authors: Behrends C.

Authors: David G McEwan, Doris Popovic, Andrea Gubas, Seigo Terawaki, Hironori Suzuki, Daniela Stadel, Fraser P Coxon, Diana Miranda de Stegmann, Sagar Bhogaraju, Karthik Maddi, Anja Kirchof, Evelina Gatti, Miep H Helfrich, Soichi Wakatsuki, Christian Behrends, Philippe Pierre, Ivan Dikic

PMID:25498145


RAB3GAP1 and RAB3GAP2 modulate basal and rapamycin-induced autophagy

Spang N, et al. Autophagy 2014. Among authors: Behrends C.

Authors: Natalie Spang, Anne Feldmann, Heike Huesmann, Fazilet Bekbulat, Verena Schmitt, Christof Hiebel, Ingrid Koziollek-Drechsler, Albrecht M Clement, Bernd Moosmann, Jennifer Jung, Christian Behrends, Ivan Dikic, Andreas Kern, Christian Behl

PMID:25495476